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Doctors newspaper online, 18.10.2019
Inflammation
It is known that physical activity protects the heart. A team has now investigated the role of anti-inflammatory metabolic changes.
BERLIN. Inflammatory processes in the body increase the risk of cardiovascular diseases. A new study presented at the Heart Days of the German Society of Cardiology in Berlin indicates that physically fit people have less inflammatory markers in their blood and are thus better protected against cardiovascular diseases.
In chronic systemic inflammation, the immune system is known to be permanently activated and releases inflammatory substances. The current study has shown that the inflammatory state, as measured by the biomarker hs-CRP (highly sensitive C-reactive protein), is prognostically important for cardiovascular disease. Already low inflammatory values below the values, as measured in clinically manifest inflammations, are therefore to be evaluated as a risk factor for cardiovascular diseases.
The team around Dr. Kirsten Lehnert from the University of Greifswald examined the relationship between physical performance and inflammatory markers in the blood of almost 1,500 people from Mecklenburg-Western Pomerania between the ages of 20 and 81 years. The physical fitness of the participants was assessed by the researchers using a load test with breathing gas measurement on the bicycle ergometer.
The higher the maximum oxygen uptake, the fitter was the subject. An increase in maximum oxygen uptake of 100 ml was significantly associated with 4.5% lower hs-CRP and 1% lower white blood cell count. Other inflammatory markers showed similar relationships. "We were able to show that higher physical performance is associated with less systemic inflammation," Lehnert concluded.
According to Lehnert, the results suggest that the widespread lack of physical activity in the population not only promotes poor physical fitness but also higher levels of inflammation, leading to cardiovascular diseases. "However, the influence of messenger substances and other factors in the context of an inflammatory reaction to the cardiovascular risk should be analyzed even more precisely," says Lehnert. (sj)
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